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Biochemistry - mod. GENERAL BIOCHEMISTRY
GIANNA FERRETTI

Seat Medicina e Chirurgia
A.A. 2013-2014
Credits 5
Hours 50
Period 2^ semestre
Language ENG
U-gov code MU01-09-11 LS549

Prerequisites

Knowledge of biology, physics and cell chemistry

Development of the course

The course aims to understand the organization of the major human metabolic pathways, the nutritional principles that  underlie it, along with the functional logic of metabolic pathways in cells, tissues and organs

Learning outcomes

At the end of the course the student should be able to know the logic biochemistry (organizational logic to functional) of the human organism. It must also be able to interpret the human needs of food, mainly heterotrophic organism. The student will also learn about the metabolism of all human organs.

Program

Lipids, carbohydrates and proteins in food. General functions of enzymes and enzyme kinetics. Coenzymes used in metabolic reactions and biochemical actionof vitamins. Structure and function of hemoglobin and myoglobin and their functions of binding and transporting oxygen.
Bioenergetics and biological oxidation: ATP. Biochemical mechanisms of regulation of major metabolic pathways. Biochemistry of the endocrine system: relationship between structure and function of  different hormones (non-protein and protein) and their role in metabolism. General principles of digestion  and absorption  of food,  as vectors of nutrients,  antinutrients and nutrients. Biochemical and pathophysiological parameters of foods.

Metabolic pathways :  The anaerobic glycolysis and pyruvate oxidation,  Krebs cycle and oxidative phosphorylation, pentose  shunt  and reduced coenzymes production,  glycogen metabolism, gluconeogenesis, glucosehomeostasis, fatty acid oxidation, ketogenesis, fatty acid biosynthesis , triglycerides and phospholipids, cholesterol and lipoprotein metabolism, transamination and    glutamate deamination, urea cycle and glutamine synthesis and  degradation of  nucleobases: uric acid. Synthesis and elimination of bile pigments: plasma bilirubin. Metabolism of organs and tissues and their functional correlations

Development of the examination
oral test

Recommended reading

a)     TITLE Biochemistry with Clinical Aspects

b)     AUTHOR Devlin T.M.

c)      PUBLISHER EDISES 2011

Courses

• Medicina e Chirurgia