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Microbiology and Clinical Microbiology - C.I. (1st year)
BRUNA FACINELLI

Seat Medicina e Chirurgia
A.A. 2017-2018
Credits 6
Hours 60
Period 2^ semestre
Language ENG
U-gov code MT05-11-11 MT510

Prerequisites

Basic principles of Biology, Genetics, Biochemistry.

Development of the course

The course has been organized in a number of lectures arranged into three didactic units.  The aim of the course is to teach the students the microbiological, physiological and pathogenic characteristics of the major groups of microrganisms of medical interest and the tools necessary for the identification and diagnosis of the etiological agents. The unit 1 deals with the basic concepts of microorganisms and their role as pathogens for humans, genetics and microbial pathogenicity, host-parasitic relationships, antimicrobials agents, microbiota, microbiome. The unit 2 deals with the major pathogenic bacterial and fungi. The unit 3 deals with laboratory methods and procedures as identification and susceptibility testing.

Learning outcomes

• Knowledge

​The principal aim of the course is to provide students with the basic concepts about the normal microbiota of the human body and the major human pathogens involved in infectious diseases, the mechanisms of pathogenicity, and the mechanisms of action and resistance of the major classes of antimicrobial agents as well as microbiological methods.

• Ability to apply the knowledge

​At the end of the course the student will know the pathogens and the indigenous microorganisms present on the body, the mechanisms of action of the main antibiotics and the phenomenon of antibiotic resistance and microbiological methods.

• Soft skills

The knowledge of of major pathogens and related aspects of epidemiology and prophylaxis will allow the student to deal with other medical disciplines such as Infectious Diseases, Hygiene, etc

Program

DIDACTIC UNIT 1 – MICROBIOLOGY - Prof. B. Facinelli

Definition and objectives of microbiology. The microbial world; metabolism, growth and reproduction of microorganisms. Microorganisms and chemical and physical agents; disinfection; sterilization. Prokaryotes: structure and functions of the constituents of the bacterial cell; mechanisms of genetic recombination in bacteria; plasmids and extracromosomal elements; antibiotics and antibiotic-resistance. Principles of microbial ecology; microorganism-guest relations; colonization and infection; microbiota and microbiome; unspecific defenses and guest specifications; pathogenicity and virulence of microorganisms. Protozoa:  biological characteristics and classification; the main pathogenic protozoal pathogens for humans. Principles of epidemiology and prophylaxis of infectious diseases; community and nosocomial infections.

 

DIDACTIC UNIT 2 -  Bacteriology and Mycology - Dott.ssa M. Mingoia

Major bacteria of medical interest: Staphylococci, Streptococci, Enterococci; sporogenic bacteria (Bacillus and Clostridium); Mycobacteria; Spirochetes; Enterobacteria; Pseudomonas and other Gram-negative non-fermenters; genus Haemophilus, Neisseria, Vibrio, Campylobacter, Helicobacter, Mycoplasma, Chlamydia. Identification of each pathogen is  emphasized and includes selection of specimens to examine, routes of transmission, isolation media, and macroscopic and microscopic characteristics as applicable.

Mycetes: biological features and classification; pathogenic activity. Major mycetes of medical interest: Candida albicans, Cryptococcus neoformans, filamentous fungi (Dermatophytes, Aspergilli), dimorphic fungi (Sporothrix schenckii, Histoplasma capsulatum, Blastomyces dermatitidis, Coccioides immitis, Paracoccidioides brasiliensis).

 

DIDACTIC UNIT 3 – MICROBIOLOGY LABORATORY TECHNIQUES - Dott. B. Bonci

From the 14th-century pandemic to today's antibiotic-resistance crisis: a historical approach to Microbiology. Sterilization and disinfection. The pre-analytical phase. Conventional Microbiology. Biochemical Systems. Immune systems. Molecular systems. The TAT in Microbiology. Automation Schemes in the Microbiology Lab. In vitro test for antimicrobial therapy. The lab in the study of resistances. Nosocomial infections

Development of the examination

• Methods for assessing learning outcomes:

Oral evaluation consisting of questions about different topics dealed in the program of the integrated course

• Criteria for assessing learning outcomes: 

The student will be evaluated according to the knowledge of the topics in the program and the skill showed about them.

• Criteria for measuring learning outcomes:

The final mark is awarded in thirtieths. The exam is passed when the rating is greater than or equal to 18. The highest marks with honors (30 cum laude) may be awarded.

• Criteria for conferring final mark:

The final mark is given considering the completeness of exposition for each reply, reviewing and comparing the ratings of each commissary. Honors are given following unanimous decision, when the score is already 30/30 and the student has demonstrated full mastery of the topics

Recommended reading

Principi di microbiologia clinica. E. Lanciotti, Casa Editrice Ambrosiana.

 

PROFESSOR CONTACT:

Prof.ssa Bruna Facinelli: Dep. Biomedical Sciences and Public Health–Microbiology Unit –UNIVPM Polo Eustachio 5° Piano 071 2206296 b.facinelli@univpm.it

Dott.ssa Marina Mingoia: Dep. Biomedical Sciences and Public Health–Microbiology Unit –UNIVPM Polo Eustachio 5° floor  071 2206295 m.mingoia@univpm.it

Dott. Bruno Bonci: Azienda Ospedaliero/Universitaria-Ospedali riuniti - Via Conca, 71 - 60126 Torrette - Ancona  071 5961 b.bonci@email.it

 

OFFICE HOURS: after telephone appointment

Courses

• Tecniche di Laboratorio Biomedico